CHEM 440
Biochemistry I
J. D. Cronk   Syllabus [ Previous | Next ] Pick a lecture:
22.header

Lecture 22. Regulatory strategies II

Wednesday 4 November 2009

Regulation of a prototypical protein kinase: 3',5'-Cyclic AMP (cAMP) and protein kinase A (PKA). Proteolytic processing of precursors as a regulatory strategy. Zymogen forms of pancreatic enzymes and their activation by specific peptide bond cleavage.

Reading: BTS6 - Ch.10, pp.288-297.
22. Summary

Lecture 22 Summary

Isoforms and isozymes: Examples include globins and lactate dehydrogenase (LDH).

Structure and function of protein kinase A (PKA).

Zymogen activation of digestive enzymes: The specific proteolytic cleavage of pancreatic serine proteases.

Secretion and activation of chymotrypsinogen

Chymotrypsin vs. chymotrysinogen.

 

Activation of enzymes by specific proteolytic cleavage

The processing of precursor forms of proteins by specific proteolysis is a phenomenon we encountered earlier in connection with insulin. Here we look at the pancreatic serine proteases, which are secreted as inactive precursor forms called zymogens.
 
 

 

 
 

Learning objectives

  • Explain the nature and purpose of zymogen activation.
  • Describe changes in the structure of chymotrypsinogen occurring upon proteolytic cleavage that account for activation

Page update in progress, 11-07-09

References

 
 
footer
[ E-mail: cronk@gonzaga.edu ]