CHEM 440
Biochemistry I
J. D. Cronk   Syllabus [ Previous | Next ] Pick a lecture:
24.header

Lecture 24. Introduction to metabolism II.

Monday 9 November 2009

Hemophilia and the regulation of clotting. Carbohydrates. Overview of metabolism. Redox reactions in biochemistry. Vitamins and cofactors. Patterns of of key reactions or metabolic motifs. Energy charge.

Reading: BTS6 - Ch.15, pp.417-429.

24. Summary

Lecture 24 Summary.

update for Fall 2009 in progress...

We'll tentatively cover hemophilia (p.296) and deregulation of the clotting cascade (pp.296-297), and then move on to review carbohydrates (Ch.11, pp.303-312) and general features of metabolism (Ch.15, p.409ff).

Oxidation states of functional groups (p.417). "Redox" cofactors (electron carriers): NAD+ (or NADP+) and FAD (pp.420-421).

 

Cofactors that act as carriers in metabolism

"Redox" cofactors (electron carriers): NAD+ (or NADP+) and FAD. Oxidation states of functional groups.

Coenzyme A is an acyl group carrier, and we'll look at acetyl CoA and other thioesters.

 

Learning objectives

  • Describe the cofactors
  • Explain how ATP, acetyl CoA, and NADPH illustrate the importance of kinetic stability in an activated carrier, and describe any structural similarities and their significance.

Page update in progress, 11-07-09

References

  1. Staunton J. Primary Metabolism: A Mechanistic Approach (1978, Oxford University Press)
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[ E-mail: cronk@gonzaga.edu ]