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Class schedule
Spring 2008 |
MONDAY |
WEDNESDAY |
FRIDAY |
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WEEK
1
16, 18 January
( Lectures 1, 2 ) |
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17
January.
Lipids, membranes,
and mitochondria (CH.18) |
19
January.
Redox potentials and
free energy (CH.18) |
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WEEK
2
21, 23, 25 January
( Lectures 3, 4, 5 ) |
MLK
Holiday |
22
January.
Electron transport chain
CHAPTER 18 |
24
January.
Redox loops and
proton pumps |
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WEEK
3
28, 30 January; 1 February
( Lectures 5 - 7 ) |
26
January.
Electron transfer
to oxygen |
30
January
ATP synthase |
1
February.
Respiratory control.
Inhibitors of ETC |
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WEEK
4
4, 6, 8 February
( Lectures 8, 9, 10 ) |
4
February.
Photosynthesis
CHAPTER 19 |
6
February.
Bacterial photosynthetic
reaction complex |
8
February.
Electron flow in photosynthesis |
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WEEK
5
11, 13, 15 February
( Lectures 11, 12 ) |
11 February.
ATP synthesis
in chloroplasts |
13
February
EXAM 1 |
15
February.
Rubisco and the
Calvin cycle (CH.20) |
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WEEK
6
18, 20, 22 February
( Lectures 13, 14 ) |
President's
Day
Holiday |
20
February.
Calvin cycle
and C4 plants |
22
February.
Pentose phosphate
pathway |
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WEEK
7
25, 27, 29 February
( Lecture 15, 16, 17 ) |
25
February.
PPP:
Enzymes & mechanisms |
27
February.
Glycogen structure
and metabolism (CH.21) |
29
February.
Regulation of glycogen
phosphorylase |
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WEEK 8
3, 5, 7 March
( Lectures 18, 19, 20 ) |
3
March.
Glycogen synthesis.
Reciprocal regulation |
5
March.
Fatty acid metabolism
CHAPTER 22 |
7
March.
Fatty acid metabolism:
Special problems |
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WEEK 9 - Spring Break (10 -14 March) |
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MONDAY |
WEDNESDAY |
FRIDAY |
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WEEK 10
17, 19, 21 March
( Lectures 21, 22 ) |
17 March
Fatty acid synthesis |
19
March
Regulation of FA synthesis
Eicosanoid hormones |
21
March
Good Friday
Holiday |
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WEEK 11
24, 26, 28 March
( Lecture 23 ) |
24
March
Easter Holiday |
26 March
Regulation of
fatty acid metabolism. |
28
March
EXAM 2 |
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WEEK 12
31 March, 2, 4 April
( Lecture 24, 25, 26 ) |
31
March.
Ubiquitin and proteasomes
CHAPTER 23
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2
April
Glutamate catabolism.
Transaminases & PLP |
4
April
PLP-dependent reactions.
The urea cycle |
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WEEK 13
7, 9, 11 April
( Lectures 27, 28, 29 ) |
7
April.
Amino acid catabolism |
9 April.
Biological nitrogen fixation
CHAPTER 24
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11
April.
Amino acid biosynthesis.
One-carbon metabolism |
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WEEK 14
14, 16. 18 April
( Lectures 30, 31, 32 ) |
14 April.
Amino acids and
further biosynthesis |
16
April.
Nucleotide biosynthesis
CHAPTER 25
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18
April.
Purine biosynthesis |
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WEEK 15
21, 23, 25 April
( Lectures 33, 34 ) |
20
April.
Ribonucleotide reductase
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25
April.
Special topics in
biochemistry (TBA) |
25
April
EXAM 3 |
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WEEK 16
28, 30 April, 2 May
( Lectures 35, 36, 37 ) |
28
April.
Special topics in
biochemistry (TBA) |
30
April.
Special topics in
biochemistry (TBA) |
2
May.
Special topics in
biochemistry (TBA) |
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FINAL EXAM
- Monday 5 May 2008, 1:00 - 3:00 pm |
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Course objectives: Building on the previous semester's work with the chemistry
of living systems, based
upon thermodynamics, kinetics, molecular structures and
mechanisms, we take up topics within the areas of bioenergetics and metabolism. Note as well it is presumed you are MCB literate (as one would be having taken BIOL 201). To begin, we examine the process of oxidative phosphorylation,
including biomembrane functionality, electron transport, and the details of ATP synthesis.
Following a complementary treatment of the light reactions of photosynthesis, we explore metabolic pathways involving pentose
phosphates, complex carbohydrates, fatty acids, amino acids, nitrogen, and nucleotides. Throughout, but especially in the second half of the course, we take up the biochemical basis of disease, and develop regulation as a unifying principle in metabolism. We will finish the semester with special topics
which in past semesters have been based on student reports. |
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Grading for this course is based mainly upon exams, although homewok, problem sets,
etc will be given consideration. Further details are provided in class.
Missed exams, late homework: I will
permit make-up exams only for students
with a legitimate, urgent excuse who have contacted me prior to
the exam or quiz. I reserve the right to deduct points from
homework that is turned in late. |
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