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Class schedule
Spring 2007 (tentative) |
MONDAY |
WEDNESDAY |
FRIDAY |
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WEEK
1
16, 18 January
( Lectures 1, 2 ) |
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17
January.
Lipids, membranes, and
mitochondria (CH.18) |
19
January.
Redox potentials
and free energy
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WEEK
2
21, 23, 25 January
( Lectures 3, 4, 5 ) |
MLK
Holiday |
23
January.
Electron transport chain
CHAPTER 18 |
25
January.
Redox loops and
proton pumps |
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WEEK
3
28, 30 January; 1 February
( Lectures 5 - 7 ) |
28
January.
Electron transfer
to oxygen |
30
January
ATP synthase |
1
February.
Respiratory control.
Inhibitors of ETC |
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WEEK
4
4, 6, 8 February
( Lectures 8, 9, 10 ) |
4
February.
Photosynthesis
CHAPTER 19 |
6
February.
Bacterial photosynthetic
reaction complex |
8
February.
Electron flow in photosynthesis |
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WEEK
5
11, 13, 15 February
( Lectures 11, 12 ) |
11 February.
ATP synthesis
in chloroplasts |
13
February
EXAM 1 |
15
February.
Rubisco and the
Calvin cycle (CH.20) |
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WEEK
6
18, 20, 22 February
( Lectures 13, 14 ) |
President's
Day
Holiday |
20
February.
Calvin cycle
and C4 plants |
22
February.
Pentose phosphate
pathway |
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WEEK
7
25, 27, 29 February
( Lecture 15, 16, 17 ) |
25
February.
PPP:
Enzymes & mechanisms |
27
February.
Glycogen structure
and metabolism (CH.21) |
29
February.
Regulation of glycogen
phosphorylase |
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WEEK 8
3, 5, 7 March
( Lectures 18, 19, 20 ) |
3
March.
Glycogen synthesis.
Reciprocal regulation |
5
March.
Fatty acid metabolism
CHAPTER 22 |
7
March.
Fatty acid metabolism:
Special problems |
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WEEK 9 - Spring Break (10 -14 March) |
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MONDAY |
WEDNESDAY |
FRIDAY |
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WEEK 10
17, 19, 21 March
( Lectures 21, 22 ) |
17 March
Fatty acid synthesis |
19
March
Regulation of FA synthesis
Eicosanoid hormones |
21
March
Good Friday
Holiday |
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WEEK 11
24, 26, 28 March
( Lecture 23 ) |
24
March
Easter Holiday |
26 March
Regulation of
fatty acid metabolism. |
28
March
EXAM 2 |
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WEEK 12
31 March, 2, 4 April
( Lecture 24, 25, 26 ) |
31
March.
Ubiquitin and proteasomes
CHAPTER 23
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2
April
Glutamate catabolism.
Transaminases & PLP |
4
April
PLP-dependent reactions.
The urea cycle |
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WEEK 13
7, 9, 11 April
( Lectures 27, 28, 29 ) |
7
April.
Amino acid catabolism |
9 April.
Biological nitrogen fixation
CHAPTER 24
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11
April.
Amino acid biosynthesis.
One-carbon metabolism |
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WEEK 14
14, 16. 18 April
( Lectures 30, 31, 32 ) |
14 April.
Amino acids and
further biosynthesis |
16
April.
Nucleotide biosynthesis
CHAPTER 25
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18
April.
Purine biosynthesis |
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WEEK 15
21, 23, 25 April
( Lectures 33, 34 ) |
21
April.
Ribonucleotide reductase
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23
April.
Special topics in
biochemistry (TBA) |
25
April
EXAM 3 |
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WEEK 16
28, 30 April, 2 May
( Lectures 35, 36, 37 ) |
30
April.
Special topics in
biochemistry (TBA) |
2
May.
Special topics in
biochemistry (TBA) |
4
May .
Special topics in
biochemistry (TBA) |
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FINAL EXAM
- Monday 5 May 2008, 1:00 - 3:00 pm |
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Course goals and philosophy
The course is a continuing exploration of the the chemical basis
of living systems, from a
molecular structure, thermodynamic, and kinetic point of view.
To begin, we examine the process of oxidative phosphorylation,
in which exergonic electron transport is coupled to the generation
of an electrochemical gradient, which in turn drives ATP synthesis.
The properties of membranes and the functioning of membrane
proteins are central to this process, and we will learn about
the fundamental features of biological membranes. We continue
with a survey of major metabolic pathways, covering pentose
phosphates, gluconeogenesis, complex carbohydrates, fatty acids
(which are major components of membranes), amino acid catabolism
and nitrogen excretion. We then take up photosynthesis, in which
light energy is harvested in the form of the chemical energy
of NADPH and ATP. Again, membrane biochemistry is a crucial
part of the story, and we will compare and contrast photosynthesis
and oxidative phosphorylation. We next consider the biosynthetic
pathways producing amino acids, nucleotides, and selected other
important biomolecules, such as porphyrins and cholesterol.
We will finish the semester with special topics
which in past semesters have been based on student reports.
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Grading
Grading for this course is based mainly upon exams, although homewok, problem sets,
etc will be given consideration. Further details are provided in class.
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