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BIOL 440 / CHEM 440 - Biochemistry I
(Fall 2007)
(updated 4-Oct-2007)
Lectures: 1:10-2:00 pm, MWF in 126 Jepson (BIOL
440, Sect. 01, CRN 10386).
Instructor: Jeff D Cronk E-mail: cronk@gonzaga.edu Phone: 323-6627
(lab - 5935)
Office: Hughes 234. Office Hours: (Fall 2007) MWF: 9:00-9:50 AM; Tue: noon - 1:30 PM; also by appt.
Required Text: Biochemistry (6th
edition) Jeremy M. Berg, John L. Tymoczko, Lubert Stryer (BTS6)
Optional texts (recommended): Student Companion
to Accompany Biochemistry (6th ed.) Gumport et al.
Course website: http://www.gonzaga.edu/faculty/cronk/CHEM440-index.html
Course synopsis: In this course,
we explore the chemical basis of living systems and our goal
is to gain an understanding of this from the point of view of
molecular structure, thermodynamics, and kinetics. We will begin
with an introduction to the macromolecules of biological systems
and their building blocks, emphasizing proteins and amino acids.
We then take up the structural foundations of protein function,
particularly enzymatic catalysis and regulation. Finally, we
begin to examine the central pathways of metabolism, which illustrate
energetic, mechanistic, and regulatory principles.
Enter the BIOL 440
/ CHEM 440 course website (Registered students only) Additional
Links: [ Biochemistry
dictionary ] [ CHEM
445 ] [ "Gonzology" ] [ NCBI ]
[ Resources ] |
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Class schedule
(Tentative) |
MONDAY |
WEDNESDAY |
FRIDAY |
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WEEK
1
29, 31 August
( Lectures 1, 2 ) |
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29
August. Biomolecules;
Carbohydrates
CHAPTERS 1, 11, 12 |
31
August. Noncovalent forces; Lipids
CHAPTERS 1, 11, 12 |
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WEEK
2
3, 5, 7 September
( Lectures 3, 4, 5 ) |
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5
September.
Membranes & bioenergetics
CHAPTERS 12, 13, 15 |
7
September.
Amino acids & peptides
CHAPTER 2 |
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WEEK
3
10, 12, 14 September
( Lectures 6, 7, 8) |
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14
September.
Protein structure
CHAPTER 2 |
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WEEK 4
17, 19, 21 September
( Lecture 9 ) |
17
September.
Stability & folding
CHAPTER 2 |
19 September
EXAM 1 |
21 September
GU Labor Day |
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WEEK 5
24, 26, 28 September
( Lectures 10, 11, 12 ) |
24
September.
Protein analysis methods
CHAPTER 3 |
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WEEK 6
1, 3, 5 October
( Lectures 13 - 15 ) |
1 October .
Protein mass spectrometry
CHAPTER 3 |
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WEEK 7
8, 10, 12 October
( Lecture 16, 17, 18 ) |
8 October.
Enzymology:
An introduction
CHAPTER 8
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WEEK 8
17, 19 October
( Lecture 19 ) |
15
October
Founder's Day Holiday |
17 October
EXAM 2 |
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MONDAY |
WEDNESDAY |
FRIDAY |
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WEEK 9
22, 24, 26 October
( Lectures 20, 21, 22) |
22
October.
Cooperativity: ATCase
CHAPTER 7, 10 |
24
October.
Catalytic strategies
CHAPTER 9 |
26
October.
Carbonic anhydrase
CHAPTER 9 |
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WEEK 10
29, 31 October; 2 November
( Lectures 23, 24, 25 ) |
29
October.
Carbonic anhydrase
CHAPTER 9 |
31
October.
Enzyme regulation
CHAPTER 10 |
2
November.
Murdock Conference
(TBA) |
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WEEK 11
5, 7, 9 November
( Lectures 26, 27 ) |
5
November.
Covalent modification
CHAPTER 10 |
7
November.
Zymogen cascades
CHAPTER 10 |
9
November
EXAM 3 |
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WEEK 12
12, 14, 16 November
( Lectures 28, 29, 30 ) |
12
November.
Metabolism & regulation
CHAPTERS 13 & 15 |
14
November.
Metabolic themes
CHAPTER 15 |
16 November
Metabolic themes
CHAPTER 15
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WEEK 13
19 November
( Lecture 31 )
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19
November.
Glycolysis
CHAPTER 16 |
21-23
November
Thanksgiving Holiday |
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WEEK 14
26, 28, 30 November
( Lectures 32, 33, 34 ) |
26
November.
Glycolysis
CHAPTER 16
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28
November.
Gluconeogenesis
CHAPTER 16 |
30 November.
Oxidative decarboxylation
CHAPTER 17 |
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WEEK 15
3, 5, 7 December
( Lectures 35, 36, 37 ) |
3
December.
Citric acid cycle
CHAPTER 17 |
5
December.
Citric acid cycle
CHAPTER 17 |
7
December.
Regulation, revisited
CHAPTERS 16 & 17 |
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FINAL EXAM
(Fall 2007) - Wednesday 12 December, 1
- 3 PM. |
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Grading: Your grade will be based on scores
in three in-class exams (100 points each), a comprehensive final
exam (200 points), homework (100 points), and a short paper (50
points). Grades will be assigned on the basis of percentage of
possible points earned, according to a scale based on the class
distribution of total scores. NOTE: It is your responsibility
to be familiar with and abide by GU's Academic Honesty Policy Missed exams, labs, late homework: I will permit
make-up exams only for students with a legitimate,
urgent, verifiable excuse who have contacted me prior to
the exam. I reserve the following rights: Scheduling and administration
of make-up exams are solely at the discretion of the instructor.
Instructor has the right to deduct points for missed quizzes,
homework that is turned in late, disruptive classroom behavior,
or lack of effort or participation. |
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