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BIOL 440 / CHEM 440 - Biochemistry I
(Fall 2016)
Lectures: 11:00-11:50 am, MWF in 001 Paccar (CRN 10888).
Instructor: Jeff D Cronk E-mail: cronk@gonzaga.edu Phone: 313-6627
Office: Hughes 234. Office Hours: (Fall 2016) Mon and Wed 9 - 11 am; also by appointment.
Text: Fundamentals of Biochemistry (4th
edition) Donald Voet, Judith G. Voet, Charlotte W. Pratt ("Voet" or "VVP4e")
Course synopsis: In this course,
we explore the chemical basis of living systems and our goal
is to gain an understanding of life from the point of view of
molecular structure, thermodynamics, and kinetics. We will begin
with an introduction to the macromolecules of biological systems
and their building blocks, emphasizing proteins and amino acids.
We then take up the structural foundations of protein function,
particularly enzymatic catalysis and regulation. Finally, we
begin to examine the central pathways of metabolism, which illustrate
energetic, mechanistic, and regulatory principles.
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Class schedule
(revised 08-31-2016) |
MONDAY |
WEDNESDAY |
FRIDAY |
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WEEK
1
31 August, 2 September
( Lectures 1, 2 ) |
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31 August
Foundations
CHAPTER 1 |
2
September
Water
CHAPTER 2 |
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WEEK 2
5, 7, 9 September
( Lectures 3, 4 ) |
5 September
Labor Day
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7 September
Aqueous chemistry
CHAPTER 2
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9 September
Nucleic acids
CHAPTER 3 |
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WEEK 3
12, 14, 16 September
( Lectures 5, 6 ) |
12 September
Amino acids
CHAPTER 4 |
14 September
Mass of the Holy Spirit |
16 September
Protein primary structure
CHAPTER 5 |
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WEEK 4
19, 21, 23 September
( Lecture 7, 8 ) |
19 September
Protein primary structure
CHAPTER 5 |
21 September
Protein primary structure
CHAPTER 5 |
23 September
EXAM 1 |
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WEEK 5
26, 28, 30 September
( Lectures 9, 10, 11 ) |
26 September
Protein structure
CHAPTER 6 |
28 September
Protein structure
CHAPTER 6 |
30 September
Stability & folding
CHAPTER 6 |
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WEEK 6
3, 5, 7 October
( Lectures 12, 13, 14 ) |
3 October
Protein function
CHAPTER 7 |
5 October
Protein function
CHAPTER 7 |
7 October
Carbohydrates
CHAPTER 8 |
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WEEK 7
10, 12, 14 October
( Lectures 15, 16, 17 ) |
10 October
Carbohydrates & lipids
CHAPTERS 8, 9 |
12 October
Lipids & membranes
CHAPTER 9 |
14 October
Membrane transport
CHAPTER 10 |
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WEEK 8
17, 19, 21 October
( Lectures 18, 19) |
17 October
Enzyme mechanism
CHAPTER 11 |
19 October
Enzyme mechanism
CHAPTER 11 |
21 October
EXAM 2 |
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MONDAY |
WEDNESDAY |
FRIDAY |
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WEEK 9
24, 26, 28 October
( Lectures 20, 21 ) |
24 October
GU Founder's Day |
26 October
Enzyme kinetics
CHAPTER 12 |
28 October
Enzyme kinetics
CHAPTER 12 |
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WEEK 10
31 October; 2, 4 November
( Lectures 22, 23, 24 ) |
31 October
Enzyme inhibition
CHAPTER 12 |
2 November
Enzyme regulation
CHAPTER 12 |
4 November
Enzyme regulation
CHAPTER 13 |
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WEEK 11
7, 9, 11 November
( Lectures 25, 26 ) |
7 November
Biochemical signaling
CHAPTER 13 |
9
November
Metabolism intro
CHAPTER 14 |
11 November
EXAM 3 |
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WEEK 12
14, 16, 18 November
( Lectures 27, 28, 29 ) |
14
November
Metabolism intro
CHAPTERS 14, 15 |
16
November
Glucose catabolism
CHAPTER 15 |
18
November
Glycolytic pathway
CHAPTER 15 |
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WEEK 13
21 November
( Lecture 30 )
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21 November
Oxidative decarboxylation
CHAPTER 17 |
23-25 November
Thanksgiving Holiday |
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WEEK 14
28, 30 Nov; 2 December
( Lectures 31, 32, 33 ) |
28
November
Citric acid cycle
CHAPTER 17 |
30 November
Bioenergetic principles
CHAPTER 18 |
2 December
Electron transport chain
CHAPTER 18 |
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WEEK 15
5, 7, 9 December
( Lectures 34, 35, 36) |
5 December
Electron transport chain
CHAPTER 18
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7 December
Oxidative phosphorylation
CHAPTER 18 |
9 December
ATP synthase
CHAPTER 18 |
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FINAL EXAM
(Fall 2016) - Thursday 15 December, 8
- 10 AM. |
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Grading is based on an absolute scale, with a (minimum) course total of 700 points. Scores
in three in-class exams and a comprehensive final
exam are the principal means of accumulating points. The remainder of points will be earned via both inside- and outside-of-class activities (e.g. quizzes, class participation, homework) at instructor discretion. Instructor has the right to deduct points for missed exams,
late work, disruptive classroom behavior,
or lack of effort or participation. Grades are assigned according to percentage of
possible points earned. It is the responsibility
of every student to be familiar with and abide by GU's Academic Honesty Policy.
Missed exams: Make-up exams are permitted only for students with a legitimate,
urgent, verifiable excuse who have contacted the instructor prior to
the exam. Scheduling and administration
of make-up exams are solely at the discretion of the instructor.
For further course information, see the syllabus posted on Blackboard and contact the instructor.
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