Lecture 18. Enzyme mechanism

Monday 17 October 2016

Introduction to enzymology. General catalytic principles.

Reading: VVP4e - Ch.11, pp.315-332.

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Summary

General catalytic principles

General properties of enzymes. Classification by reaction type. Stereospecificity. Geometric (steric) and electrostatic complementarity. "Lock-and-key" and "indiuced fit" models for enzyme-substrate recognition. Reaction coordinate diagrams for enzyme mechanisms; activation free energy and transition state theory. Drawing reaction mechanisms.

See the Enzymology: An introduction topics page.